منابع مشابه
Prognostic DNA methylation biomarkers in ovarian cancer.
PURPOSE Aberrant DNA methylation, now recognized as a contributing factor to neoplasia, often shows definitive gene/sequence preferences unique to specific cancer types. Correspondingly, distinct combinations of methylated loci can function as biomarkers for numerous clinical correlates of ovarian and other cancers. EXPERIMENTAL DESIGN We used a microarray approach to identify methylated loci...
متن کاملSingle Gene Prognostic Biomarkers in Ovarian Cancer: A Meta-Analysis
PURPOSE To discover novel prognostic biomarkers in ovarian serous carcinomas. METHODS A meta-analysis of all single genes probes in the TCGA and HAS ovarian cohorts was performed to identify possible biomarkers using Cox regression as a continuous variable for overall survival. Genes were ranked by p-value using Stouffer's method and selected for statistical significance with a false discover...
متن کاملUpdate on the utility of prognostic biomarkers in ovarian cancer
There is considerable interest in the gynecologic cancer community for the development of biomarkers that will be of utility in routine management of women with advanced ovarian cancer. However, at the present time, there remains limited evidence for the usefulness of any such test other than the serum cancer antigen (CA)-125 level, employed to monitor the course of disease in response to treat...
متن کاملPlasma miRNAs as Diagnostic and Prognostic Biomarkers for Ovarian Cancer
BACKGROUND Most (70%) epithelial ovarian cancers (EOCs) are diagnosed late. Non-invasive biomarkers that facilitate disease detection and predict outcome are needed. The microRNAs (miRNAs) represent a new class of biomarkers. This study was to identify and validate plasma miRNAs as biomarkers in EOC. METHODOLOGY/PRINCIPAL FINDINGS We evaluated plasma samples of 360 EOC patients and 200 health...
متن کاملOvarian cancer biomarkers in urine.
In this issue of Clinical Cancer Research , Ye et al. (1) have taken steps to address the pressing need for the identification of biomarkers for use in detecting ovarian cancer. For the past 30 years, the statistics have remained the same. The majority of women who develop ovarian cancer will die of this disease. It is the fifth leading cause of all female cancerrelated deaths in North America,...
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ژورنال
عنوان ژورنال: Cancer Biomarkers
سال: 2011
ISSN: 1875-8592,1574-0153
DOI: 10.3233/cbm-2011-0212